Prime-Boost Approach

  • The prime-boost regimens have been shown to be an effective approach to induce both humoral and cellular immune responses. Homologous prime-boost strategy contains the same formulation used in both the prime and boost regimens. Heterologous prime-boost approaches involve different formulations used in more than one injection.
  • It has been applied for the development of vaccines against important infectious diseases such as HIV, SIV, HCV, HSV, and HBV indicating promising results even in clinical trials.

Obstacles of tumor vaccines

  • Immunosuppressive tumor microenvironment (TME)

  • Resistance to tumor vaccines
  • Vaccine + OV:
    Heterologous Prime-Boost

  • Intratumoral OV to BOOST anti-tumor immunity by