Clinical Trials

Virogin is dedicated to bringing next-generation immuno-oncolytic therapeutics to the clinic through our robust pipeline.

HSV-1
Backbone

Therapy

FEATURES

Indication

Region

Registration
Number

Phase

IND Approval

Phase 1

Phase 2

TTDR
VG201

Payloads: IL-12, IL-15/IL-15Rα​

Enhanced viral replication in CEA+ tumors​

Advanced solid tumors

ChinaUS

TTDR
VG201

Payloads: IL-12, IL-15/IL-15Rα​

Enhanced viral replication in CEA+ tumors​

​Advanced solid tumors

United StatesUS

Attenuated: Deleted ICP 34.5
VG161* + Nivolumab

Payloads: IL-12, IL-15 / IL-15Rα, PD-L1 blocking peptide​

Advanced gastric cancer

ChinaUS

Attenuated: Deleted ICP 34.5
VG161*

Payloads: IL-12, IL-15 / IL-15Rα, PD-L1 blocking peptide​

Intrahepatic cholangiocarcinoma (ICC)

ChinaUS

Attenuated: Deleted ICP 34.5
VG161*

Payloads: IL-12, IL-15 / IL-15Rα, PD-L1 blocking peptide​

Primary liver cancers

ChinaUS

Attenuated: Deleted ICP 34.5
VG161*

Payloads: IL-12, IL-15 / IL-15Rα, PD-L1 blocking peptide​

Advanced solid tumors

ChinaUS

Attenuated: Deleted ICP 34.5
VG161*

Payloads: IL-12, IL-15 / IL-15Rα, PD-L1 blocking peptide​

Advanced solid tumors

AustraliaUS

Attenuated: Deleted ICP 34.5
VG161*

Payloads: IL-12, IL-15 / IL-15Rα, PD-L1 blocking peptide​

Hepatocellular carcinoma (HCC); Intrahepatic cholangiocarcinoma (ICC)

United States US

*VG161 to be developed for the Greater China market in partnership with CNBG, a Sinopharm Subsidiary (Virogin Biotech retains worldwide rights excluding Greater China)
IND = Investigational New Drug; TTDR = Transcription & translation dual regulation; ICP = Infected cell protein; IL = Interleukin; CEA = Carcinoembryonic antigen

Expanded access to any of Virogin’s investigational products can only be requested by a licensed physician who is willing to oversee the patient’s treatment, files the necessary paperwork with FDA and IRB, and is responsible for patient care and reporting.  

Submit a request below:

For additional information, refer to the U.S. FDA website: Expanded Access | Information for Physicians | FDA